Lysosome biology in autophagy
نویسندگان
چکیده
منابع مشابه
Lysosome calcium in ROS regulation of autophagy.
Lysosomes, the cell's recycling center, undergo nutrient-sensitive adaptive changes in function and biogenesis, i.e., lysosomal adaptation. We recently discovered that lysosomes also mediate the cell's "survival" response (i.e., autophagy) to oxidative stress through the activation of TFEB (transcription factor EB), a master regulator of lysosome biogenesis and autophagy. MCOLN1/TRPML1, the pri...
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The search for a single silver bullet for the treatment of cancer has now been overshadowed by the identification of multiple therapeutic targets unique to each malignancy and even to each patient. In recent years, autophagy has emerged as one such therapeutic target. In response to both therapeutic and oncogenic stress, cancer cells upregulate and demonstrate an increased dependence upon this ...
متن کامل[Structural biology of autophagy].
生命は自身の構成要素,特にタンパク質の合成と分 解のバランスを保つことで恒常性を維持している.タ ンパク質の分解は 2 つの主要な分解系,すなわちユビ キチン・プロテアソーム系と液胞・リソソーム系が 担っている.分解コンパートメントである液胞・リソ ソームへ細胞内のタンパク質やオルガネラなどを輸送 し,分解するシステムはオートファジーとよばれ,い くつかの種類が存在するが,本稿ではそのうち最も主 要な過程であるマクロオートファジーのことをオート ファジーとよぶ.オートファジーによるタンパク質分 解は以下の過程で進行する 1).まず細胞質内に突如隔 離膜が出現する.隔離膜は伸張しながら細胞質の一部 をランダムに取り囲み,二重膜構造体であるオート ファゴソームを形成する.オートファゴソームは酵母 や植物では液胞,哺乳類ではリソソームと融合し,内 膜ごと内容物が各種加水分解酵素の働きで分解...
متن کاملLysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy.
Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins in lysosomes. The limiting step of this type of autophagy is the binding of substrates to the lysosome-associated membrane protein type 2A (LAMP-2A). In this work, we identify a dynamic subcompartmentalization of LAMP-2A in the lysosomal membrane, which underlies the molecular basis for...
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In pancreatic β-cells, liver hepatocytes, and cardiomyocytes, chronic exposure to high levels of fatty acids (lipotoxicity) inhibits autophagic flux and concomitantly decreases lysosomal acidity. Whether impaired lysosomal acidification is causally inhibiting autophagic flux and cellular functions could not, up to the present, be determined because of the lack of an approach to modify lysosomal...
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ژورنال
عنوان ژورنال: Cell Discovery
سال: 2020
ISSN: 2056-5968
DOI: 10.1038/s41421-020-0141-7